Hi @per_coh 

Greetings from the Freshworks community!

We understand you want to send an auto-response only for Twitter DMs. Unfortunately, in Freshdesk, we do not have the provision to identify if it is a tweet or DM, and it can be identified only as Twitter as a whole. However, if twitter configurations are made so that the DMs are routed to specific groups, we can use automation rules to achieve this. - https://developer.freshdesk.com/api/#reply_ticket

Sample rule screenshot for your reference:

Feel free to drop a note here incase of further queries.